Cell Division
The proposal that cells divide purely mechanically when they reach a
critical size opens up fascinating perspectives. If cells bud off
daughters in much the same way that drips bud from leaking taps, then
division is something that just periodically happens to a cell.
An extraordinary event overtakes it - the cell is torn in two.
If this is the case, then if both daughters of a dividing cell are to
live, they must both have a full complement of the various internal
components that are required for their self-maintenance. These components,
in real biological cells, would be ribosomes, genes, mitochondria, etc.
If a cell doesn't have a full comlement of components, it will most
likely be unable to maintain itself, and will disintegrate.
Since a cell is going to divide in two, it has to have at least 2
copies of each component ready before division occurs, if there is to
be any chance of both daughters having at least one of each component.
But, if the chance of any single component ending up in one daughter
rather than the other is one in two, or 1/2, and there several different
types of component, then the more components there are, the less likely
it is that both daughters will contain at least one representative of
each component. It becomes more likely that, in many cases, both copies
of a component will end up in one daughter, leaving the other daughter
devoid of that component. If one daughter ends up with both copies of
one component, and the other daughter ends up with both copies of another
component, then assuming that these components are crucial for cell
maintenance, both daughter cells will not survive. Cell division will
result in the death of one or both daughters. Clearly, if cells which
divide are going to carry on living, they have to find ways to ensure
that both daughters have a full complement of components.
One way to ensure that both daughter cells get at least one copy of
each cell component is to have multiple copies of each component. If
there are 10 copies of each component, rather than just 2, it's unlikely
that all 10 will end up in one daughter.
In fact, if there are n copies of a particular component, the
probability of all n of them ending up in one daughter is 1/2n.
And the probability that both daughters will have at least one copy of
that particular component is thus 1 - 1/2n.
Given N different types of components, of which there are n copies of
each, the probability P that both daughters will have at least one copy
of each type of component is given by
P = (1 - 1/2n)N
Number of
different
components
|
Number of
copies of each
component
|
1 |
7 |
2 |
8 |
3 |
9 |
4 |
9 |
5 |
9 |
10 |
10 |
100 |
14 |
1000 |
17 |
10,000 |
20 |
100,000 |
24 |
1,000,000 |
27 |
|
Given this equation, it is possible to work out how many copies of each
type of component are needed to be, say, 99% sure that both daughters
will have at least one of each component.
The table to the left gives the number of copies required for at least
99% probability of both daughters having one copy of each component.
Thus, given only one component, there have to be 7 copies for >99%
chance of both daughters getting a copy. But given a million components,
there only need be 27 copies to achieve the same probability.
|
Assuming that, as cells become more complex, they acquire more
components, then assuming that each component has unit volume,
the volume of components is N x n. As the numbers of components
increase, the cell has to do a lot of work to produce the required
numbers of copies. Also, as the number of components increases,
cell size increases, threatening to trigger division.
One way that a cell can reduce the amount of work it has to do is
to bundle components together. If a cell has 10,000 genes coding for
different proteins, then if they are all separate, it needs to make
20 copies of each. But if the 10,000 genes are attached to each other in one
giant chromosome, it only has to make 7 copies of each
chromosome - assuming that there are no other components.
The result is that the cell need do less than half the work, to
produce fewer components.
But if each daughter cell only needs one copy of these chromosomes,
it would be preferable if only 2 copies were made, rather than 7 copies.
And there is a way of ensuring that both daughter cells
each get one of the two copies. This relies on the fact that when a
cell divides in two, the cell membrane divides into two parts. One
half goes to one daughter, and the other half to the other, like a
potato jacket being cut in half.
If one copy of a component (or set of components) is attached to
the cell membrane at some point, and a second copy is attached to the
cell membrane opposite, then when the cell divides, it's almost certain
that one copy will be drawn into one daughter, and the other copy into
the second daughter.
But how does a cell find the opposite internal face of the cell?
If internal bracing struts appear within compressed cells, then
one way to find opposite points would simply be to grow a rigid strut
within the cell. If the ends of this strut can slip along the internal
face of a spherical cell, then as the strut grows it will gradually reach
a maximum length when the strut passes from one internal face through
the centre of a spherical cell to the opposite face.
If the strut then continues to grow, and the cell walls resist, then the
strut will bend. The bent strut will exert a force against the cell
walls. If there are several struts, the net force exerted will be
a simple multiple of the force exerted by a single bent strut.
As the struts grow, they bend more, and the force they exert on the
cell wall must tend to push the cell wall outwards, and draw the
equatorial cell wall inwards.
The point where bending stresses are highest is at the middle of the
strut, and it is here that a strut is likely to break. When one strut
breaks, the stress in the remaining struts will increase, and the
likelihood is that they also will snap along the cell equator.
It simply needs one copy of a chromosome to be attached to each end of
these struts to ensure that a copy goes to each daughter.
And biological (eukaryote) cells do in fact do something like this, forming
spindles from one side of the cell to the other, on which the two
copies of the cell chromosomes are held. Other cell components, such a
ribosomes and mitochondria appear to exist in sufficient numbers in
the cell cytoplasm for them to most probably be represented in
both daughters after division.
This account of cell division all but inverts the standard DNA-centred
explanation of cell division. Cell division happens because of the
mechanical characteristics of the enlarging cell, and all other cell
processes are a consequence of this division - multiple components, chromosome
and other organelle formation, and spindle cells. Division is the primary
event, and the cell components just go along with it, and have learned to
live with it, and perhaps subsequently to acquire some degree of
control over it.
If there is any truth in this mechanical account of cell division,
then there is no more a "goal" to
reproduction than it is the "goal" of a tap to produce drips.
Reproduction - cell division (and this includes both mitosis and meiosis)
- just happens spontaneously, in the right circumstances. Life isn't
trying to reproduce. Cells just happen to divide occasionally. They
would do so even if they were entirely devoid of genes. The role of genes
is to provide instructions for synthesizing proteins, as one part of
the many processes that tke place within cells.
In this approach, division was one of the first developments in
the evolution of cells. And assuming that the earliest cells contained
multiple copies of a few simple components, cell growth regularly
resulted in division with both daughters containing a full complement
of components. If then, over time, new components were added, then as
the numbers of different components increased, the likelihood of
successful reproduction decreased. Cells then began increasing the
likelihood of success by reducing the numbers of components, by
bundling them together into larger units - organelles. When the
number and size of components grew still further, cells began to
form spindles to hold components to opposite internal faces of the
cell, and reduced the number of copies of each component to just two.